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No major adverse events occurred during the 3-month study period.

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Interestingly, the use-dependent inhibition of hippocampal neurons was dependent on the duration of the voltage step, suggesting ranolazine does not selectively affect the open state and may also interact with inactivated states.

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To understand myocardial metabolism in HF, it is important to first have a solid understanding of myocardial metabolism in the normal heart and to understand the complex pathophysiology of HF.

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Antiarrhythmic drugs, such as lidocaine, amiodarone, and epinephrine, may also be indicated to stabilize heart rhythm if the patient has arrhythmias.

Stanley: CV Therapeutics, consultant and recipient of research funding related to ranolazine; Servier, paid speaker and consultant on trimetazidine.

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