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When a surrogate mAb is used, studies should be performed to show that the target of the surrogate mAb is expressed in the same cells and tissues in the mouse as the human target is in humans, and that the specificity and pharmacological activity of the human and surrogate mAbs are similar, as described above.

The underlying mechanisms may involve cytokine-mediated induction of apoptosis, which appears, in part, related to the formation of ceramide, the down-regulation of the expression of erythropoietin receptors on progenitor cells, impaired formation and activity of erythropoietin, and a reduced expression of other prohematopoietic factors, such as stem-cell factor.

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The route of administration can also play a critical role in product immunogenicity.

Teething babies often get a rash from drooling, so gently dry her face frequently.

At present, there are no data available on the use of darbepoietin alfa intraperitoneally.

All randomized subjects who met enrollment criteria and received at least 2 cycles of study drug were considered evaluable for efficacy.

Circulating anticoagulants inhibit clotting factors, causing excess hemorrhage.

Furthermore, even if molecular characteristics and bioavailability are similar between products, it can- not be assumed that their clinical activity will be the same.

Osuseni listovi koprive fino se melju, pa se zatim presuju u tablete koje se daju u prvome redu malokrvnoj djeci, ili djeci koja nisu rasla na majcinom mlijeku.

Shifts in the mouth and the food that we eat may assist to model the disruption of the gut barrier and allow us to understand diseases all over the body.

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The search for an underlying cause of iron deficiency should include a history taking to rule out a dietary cause.

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